Systems
Description: The Roger Brent lab at Fred Hutchinson Cancer Research Center studies the quantitative operation of the systems that living cells use to sense, represent, transmit, and act upon information to make decisions that determine their future fates.
yeast (113) computational biology (106) cell signaling (37) gene expression (36) basic sciences (11) phenotype (6) public health sciences (5) translational research program (4) brent lab (1) roger brent (1)
The Brent lab studies the causes and consequences of non-genetic variation in cell signaling and downstream phenotype. Our current work studies systems level mechanisms by which evolved and synthetic S. cerevisiae signaling systems can limit the effects of this variability. We are building on this knowledge to construct chemically tunable, variation suppressed controllers of gene expression in yeast and in higher eukaryotes. By developing and distributing such "expression clamped" controllers to researchers
We have recently begun an applied project that uses deep neural networks that help augmented reality systems provide guidance for researchers performing lab procedures.
These projects support the lab mission of working to accelerate the pace of scientific discovery over the course of the 21st century. To this end, lab members are encouraged to consider the anthropology of the contemporary, here including the regulatory, economic, political and social frameworks within which the lab's research functions, and the ways that increases in biological knowledge and capability are impacting human affairs.
Systems