Primary human intestinal organoid infected with coxsackievirus B. Actin staining in red and viral RNA is green (DAPI-stained nuclei in blue).
We are interested in defining the mechanisms by which enteroviruses enter and replicate in the GI tract and how this tissue responds to these infections. For these studies, we utilize human and mouse stem cell-derived enteroids and in vivo mouse models and focus on clinically relevant enteroviruses including coxsackievirus B (CVB), echoviruses, enterovirus 71 (EV71), and enterovirus D-68 (EV-D68).
Human trophoblast organoid. SDC-1 staining in green and cytokeratin-19 is in red (DAPI-stained nuclei in blue).