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D2d Study The D2d Story -
Description: The D2d Study is a large-scale clinical trial to investigate if vitamin D supplementation helps prevent or delay type 2 diabetes in adults who are at high risk for diabetes (pre-diabetes). "Past observational studies have suggested that higher levels of vitamin D may be beneficial in preventing type 2 diabetes.
We continue to analyze study data to examine the effect of vitamin D supplementation on additional outcomes, including new onset cancer and cardiovascular disease. For a list of D2d publications, visit our publications page.
D2d is a large-scale NIH-supported trial to test whether vitamin D supplementation reduces diabetes risk in adults with prediabetes. The main results were published in the New England Journal of Medicine. Vitamin D supplementation did not significantly lower diabetes risk (hazard ratio 0.88; 95% CI 0.75 to 1.04). D2d and two other diabetes prevention trials (in Norway and Japan) among people at risk for diabetes have reported nearly identical results. We recently published a systematic review in this topic
Currently, we do not know how large the risk of developing diabetes is among people with pre-diabetes, as defined the American Diabetes Association criteria. Some researchers think that we need to screen for pre-diabetes and intervene to keep glucose levels as normal as possible. Others advocate that the current definitions of pre-diabetes risk unnecessary medicalization and create unsustainable burdens for health care systems. D2d will define the natural history of diabetes and, as such, will reconcile the
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D2d Study The D2d Story -