gao-lab.org - Gao Lab – Bioinformatics and Computational Genomics

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Life is an organized arrangement of cells, but any individual cell struggles to function independently once detached from a living organism. Therefore, a comprehensive understanding of cell functionality requires considering the microenvironment and spatial location in which cells exist. The rapid development of spatial omics technology greatly facilitates the study of cell function at the Read more about An accurate computational method for cross-platform, multi-modal spatial omics alignment and integratio

Through the process of transcription and translation, protein-coding genes (hereinafter referred to as genes) can guide the synthesis of proteins that are crucial to life activities, and then affect the physiological or pathological traits of living organisms. Thus, genes are the basic functional units in cells. Research in the past decades has shown that in Read more about Mol. Biol. Evol. | Genome-wide identification of gene loss events suggests loss relics as a potential source of functional lncRNAs in h

The GLUE study (Multi-omics single-cell data integration and regulatory inference with graph-linked embedding) published in Nature Biotechnology was recently awarded by Genomics, Proteomics and Bioinformatics (GPB) as China’s top ten bioinformatics advances of 2022.   With rapid advances in recent years, single-cell omics technologies have become essential tools for studying cellular function and gene regulation. Read more about GLUE for China’s top ten bioinformatics advances of 2022 […]

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