Description: Single Molecule Microscopy Lab at the University of Copenhagen
nhs (650) fluorescence microscopy (29) university of copenhagen (27) single molecule (6) protein dynamics (3) nikos hatzakis (2) hatzakis (2) hatzakis lab (2) hatzakis group (2) smfret (2)
The main objective of our lab is to augment our understanding on the inner workings of enzymes and decode how conformational dynamics encode enzymes’ capacity to accelerate chemical transformations while maintaining the functional plasticity of accepting structurally diverse substrates. Harnessing this knowledge is the founding step to tackle the daunting tasks of a) design novel drugs in silico and b) the design of novel biocatalysts with tailor made functionalities. We approach this formidable challenge b
Adaptive immunity in bacteria is accomplished by the CRISPR system, and CRISPR-associated proteins (Cas). Proteins coupled with RNA are guided by this system to recognize and cleave foreign genetic material. As such, it’s also a powerful method for genome editing, and is receiving lot of bio technical and medical attention currently. By using single molecule FRET we can study this system in great detail, and obtain a wealth of structural and kinetic information, when combining with other techniques. Read ho
By employing single particle tracking on novel nano-carriers in drug delivery, we are able to investigate their interactions with biological samples and simultaneously monitor particle mobility and drug release in live human cells. We aim to utilize the methodology to develop and optimize site specific and fast delivery of tailor made pharmaceuticals. To do so, we deploy advanced statistical analysis in combination with machine learning - thus deciphering the mechanistic details that governs interactions at