ALTA
ALTA
Description: Mechanisms underlying hepatocellular carcinoma pathogenesis and impact of co-morbidities
approach (290) carcinoma (30) pathogenesis (16) hepatocellular (1) co-morbidities (1)
Mechanisms underlying hepatocellular carcinoma pathogenesis and impact of co-morbidities ageing of the immune system
Hepatocellular carcinoma (HCC) is the most common liver malignancy , with an estimated 750,000 new cases and 695,000 deaths per year, rating third in incidence and mortality in the world . Whilst incidence and mortality for other cancers are declining, HCC represents an increasing public health problem in Europe with men having a higher incidence than women. Several liver diseases lead to HCC and become per definition co-morbidities, such as nonalcoholic steatohepatitis (NASH) or hepatitis B and C virus inf
HEP-CAR will focus on three leading HCC associated co-morbidities, specifically NASH and hepatitis B and C infection . Non-biased genetic and lipidomic screens will define cellular pathways that are deregulated in HCC and the impact of co-morbidities and gender. Next to established patient cohorts, several in vitro and in vivo models are available to evaluate the role of co-morbidities as drivers of host oncogenic pathways and to provide much needed pre-clinical models for mechanistic studies and future dru
ALTA
ALTA