Description: Webpage of Philip L. Hooper, M.D.
stress (5082) diabetes (2651) inflammation (262) metabolic syndrome (29) heat shock proteins (2) xenohormesis (1)
My research over the past decade has focused on the pathogenesis of the metabolic syndrome, type 1 diabetes, and type 2 diabetes mellitus.
My work has established that the abnormalities of heat shock proteins (HSPs) in these diseases is paramount to understanding their pathogenesis. In insulin resistant states and diabetes, heat shock factor 1 (HSF-1) is low in insulin sensitive tissues, resulting in low HSP levels. Low HSPs make organs vulnerable to injury, impair the stress response, accelerate systemic inflammation, raise islet amyloid polypeptide, and increase insulin resistance. Feeding this cycle are excess saturated fat and calorie cons
P.L. Hooper, L.E. Hightower, P.L. Hooper (2012) Loss of stress response as a consequence of viral infection: Implications for disease and therapy , Cell Stress and Chaperones , published online 14 July, 2012.