Description: Homepage for Duke course BCH622: Structure of Biological Macromolecules taught by Dave and Jane Richardson
course (4006) tutorial (1725) richardson (250) mage (55) macromolecular structure (1) kinemage (1)
Web service for all-atom contact, conformation, & geometry analysis of x-ray or NMR models, with automated correction of Asn/Gln/His flips. As a structure user, you can easily evaluate reliability of the parts you care about.
Our research primarily focuses on development of validation techniques to aid in the creation of higher quality 3D biological macromolecular structures. Our work is applicable to proteins and nucleic acid structures determined using a variety of structural determination techniques, including X-Ray crystallography, NMR, and cryo-EM. Some highlights: All-atom contacts ; structure validation & improvement; protein backbone motions; protein sidechain rotamers; RNA backbone rotamers .
Our lab software focuses on 3D visualization and structural validation of macromolecular structures. Most current RLab software is distributed with as part of the PHENIX software suite or available in MolProbity . For those interested in using our software as part of a bulk run, please contact us for assistance.