Description: Home page of the Molecular virolgy research group headed by Prof. James Stewart, based at the University of Liverpool, UK
virus (1274) rsv (72) ebv (69) epstein-barr virus (20) herpesvirus (2) mhv-68 (1) muhv-4 (1) hhv-8 (1) kshv (1) kaposi's sarcoma-associated herpesvirus (1)
The Molecular Virology Research Group is based at the University of Liverpool and is led by Prof. James Stewart. We employ and integrative and molecular approach to study the immunity to and pathogenesis of virus infections of man and animals.
Most of my group's current research programme is centred on the use of influenza A virus (IAV), respiratory syncytial virus (hRSV) and murine γ-herpesvirus-68 (MHV-68) to study immunology, virus-host interactions and pathogenesis in the respiratory tract. These studies use virus reverse genetics combined with transgenic mouse technology, molecular pathology, transcriptomics and proteomics to dissect pathogenic mechanisms. The following paragraphs outline our current work.
The role of autophagy in virus pathogenesis One major project, funded by the BBSRC, is the role of non-canonical autophagy (LC3-associated phagocytosis or LAP) during influenza A virus (IAV) infection in collaboration with the Wileman group (Quadram Institute) LAP is a recently-characterised phagocytic pathway that plays important roles during immunity to infectious agents including viruses. We have generated a transgenic mouse that is deficient in LAP and this is being used, along with other conditional kn