Surgical consistency is critical for repeatable electrode insertions in multi-subject datasets. The NeuralGlider Inserter standardizes electrode insertions for all users so researchers can eliminate variability in electrode placement methodology (e.g., velocity, depth, tissue deformation) and ensure reproducibility across experiments. This consistency allows for accurate comparison of data, reliable trend analysis, and meaningful statistical interpretations.
Tissue deformation during electrode insertion can have significant repercussions in preclinical research, inducing inflammation, gliosis and loss of neuronal density and complexity. Chronic tissue compression negatively impacts the localization of cortex-spanning electrodes, requiring post-hoc channel alignment between subjects, reducing the number of active channels and increasing data analysis duration and complexity. Additionally, chronic tissue strain has been shown to negatively impact neuronal excitab
The NeuralGlider Inserter uses ultrasonic micro-vibration to reduce forces and resultant dimpling during neural implant insertions. It has been tested in vitro, ex vivo, and in vivo with a variety of neural implants. The reduced insertion force facilitates slow (0.1 mm/s), accurate implant insertions while minimizing displacement/dimpling of the cortical surface, helping to preserve the integrity of the underlying neural tissue.