neuroglide.org - Homepage - Actuated Neuroscience

Description: Actuated Neuroscience designs preclinical medical devices that assist in neural implants and insertions. Learn more about the NeuralGlider Inserter and the extensive amount of research our engineering team has put in to set the foundation for a precise insertion.

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Look Familiar? You just spent months prepping for an insertion procedure, and are finally to the point that you get to gather the invaluable data that your team needs. Despite your best efforts, you walk away with an unsuccessful insertion, due to either foreign body response or insertion failure. Thousands of dollars and months of effort down the drain. The NeuralGlider Inserter improves insertions, getting you better insertions with less tissue damage.

Dr. Xinyan Tracy Cui and her lab at University of Pittsburgh developed new probes that can measure neuron activity and dopamine levels simultaneously.  These techniques provided insight as to how circadian rhythms influence dopamine levels in mammals.  These custom-made probes were optimized within the Cui lab, so when they used the NeuralGlider Inserter they were able to prevent dimpling and have a standardized and precise targeting in a brain center involved in reward and motor learning.

In this groundbreaking study Juan Pascual at UT Southwestern and colleagues implanted penetrating electrodes into the brain of pigs to make specific comparisons to human brain activity. Because the team was using multiple probes that were as thin as 8 micrometers, they used NeuralGlider during implantation to measure the responses of individual neurons, minimizing damage and ensuring the longevity of these probes. NeuralGlider enabled them to implant in pigs, which are low cost large animals, and this is a