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Current Issue Table of Contents: 10 May 2023 Volume 43, Issue 19
Immunofluorescent image of a cross section of a non-human primate (Macaca fascicularis) spinal cord, dosed intravenously with HSC15/ARSA-V5 gene therapy vector demonstrating successful ARSAV5 expression (magenta) in cells, including neurons and glia, that endogenously express cynomolgus Arsa (green) and where colocalization of both signals appears in white. The detection of an ARSA-V5 signal in the spinal cord confirms that HSC15/ARSA-V5 crossed the blood-brain barrier in larger species. For more informatio