PalmerLab.org -
RatGTEx
Omics Portal For Addiction Research
PalmerLab.org -
Hardiman Lab
Center overview. There are few effective therapies to treat drug abuse and dependence, despite the urgent need to develop more effective treatments. A major impediment to the development of such treatments is our extremely limited understanding of the biological basis of drug abuse. While human genome-wide association studies (GWAS) have begun to elucidate genes that influence various traits relevant to drug abuse, they are still unable to attribute more than a small fraction of the heritable variance to sp
Why rats? The use of rats is critical because many of the phenotypes we study were developed using rats and difficult or impossible to adapt for mice. We utilize a unique rat population: the N/NIH heterogeneous stock ( HS ), which is derived from 8 fully sequenced inbred rat strains and has been maintained as an outbred population for 90+ generations. This population is designed to resolve quantitative trait loci ( QTL ) to regions that are small enough to permit identification of specific genes. Heterogene
What behaviors do we study? We have carefully selected a range of behavioral traits that model behavioral predispositions and inferred psychological processes that are known to influence vulnerability to drug abuse in humans. This approach is consistent with the NIMH Research Domain Criteria ( RDoC ) which seeks to emphasize traits rather than diagnoses. Several psychological domains are represented. Dr. Paul Meyer from the University at Buffalo ( Research Project 1 ) examines intravenous self-administrat
PalmerLab.org -
RatGTEx
Omics Portal For Addiction Research
PalmerLab.org -
Hardiman Lab