THE CHALLENGE Sustainable global protection from COVID-19 by 2022 by supporting country governments and frontline immunization workers to take the lead in equitably delivering COVID-19 vaccines. Tens of millions of people have been infected, more than a million people have died, the estimated loss to global GDP over 2020 to 2021 attributed to the pandemic is $9 trillion USD, and the pandemic will likely cause an estimated 34 million people to fall below the extreme poverty line in 2020 alone.