Simulacrum
Simulacrum
Description: Researches that interest me
Researches that interest me
Natural products have been a major source of medicine throughout history. In ancient Egypt, people already used willow bark to ease pain and fever. Its active extract, salicin has a chemical substructure like aspirin. However, the extraction or synthesis of natural products seems to be a major issue when considering modern industry requires to use HTS (High Throughput Screening) process or build a large chemical library. 1 As a result, for the past few decades, pharmaceutical companies tend to de-emphasize
This raises problems: There is a demand to bring more novel drugs to the market due to the increasing disease diversity. 1 However, even though the expense on R&D department of pharmaceutical companies is increasing every year, the number of annual approved drugs does not increase (even less compared to that in 1990s). There is a large failure rate in phase II and phase III due to lack of efficacy or off-target side effects. 3
Simulacrum
Simulacrum